CCR-3 Antibody

C-C chemokine receptor type 3 (CCR-3) is a receptor for C-C type chemokine. CCR-3 binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. The activation of CCR-3 subsequently transduces a signal by increasing the intracellular calcium ions level. CCR-3 is an alternative coreceptor with CD4 for HIV-1 infection. Overexpression of CCR-3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR-3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T cell-mediated mucosal inflammation.