CBX4 Antibody

E3 SUMO-protein ligase CBX4 (CBX4) is a protein ligase which facilitates SUMO1 conjugation by UBE2I. CBX4 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones; and it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.