Cathepsin K Inhibitor Screening Kit (Fluorometric)

Alternate Name :

Tag Line :

Only kit on the market to screen Cathepsin K inhibitors

Storage Conditions: -80°C

Shelf life: 12 months

Summary :

• Detection method- Fluorescence (Ex/Em = 400/505 nm)
• Applications- Screen/study/characterize potential inhibitors of Cathepsin K.

Detection Method: Fluorescence (Ex/Em = 400/505 nm)

Features & Benefits:

• Simple & convenient
• High-throughput adaptable assay to screen/study/characterize the potential inhibitors of Cathepsin K
• Cathepsin K inhibitor, FF-FMK is included in the kit

Description:

Cathepsin K (CTSK, EC 3.4.22.38), a lysosomal cysteine protease, is involved in osteoclastic bone remodeling and resorption. In addition, it also degrades collagen, gelatin and elastin. Biovision’s Cathepsin K Inhibitor Screening Kit utilizes the ability of active Cathepsin K to cleave the synthetic AFC based peptide substrate to release AFC, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin K-specific inhibitor, the cleavage of this substrate is reduced/abolished resulting in decrease or total loss of the AFC fluorescence. This simple and high-throughput adaptable assay kit can be used to screen/study/characterize potential inhibitors of Cathepsin K.