Cathepsin B (CTSB) Inhibitor Screening Kit (Fluorometric)

Alternate Name :

Tag Line :

Only kit on the market to screen Cathepsin B inhibitors

Storage Conditions: -20°C

Shelf life: 12 months

Summary :

• Detection method- Fluorescence (Ex/Em = 400/505 nm)
• Applications- Screen/study/characterize potential inhibitors of Cathepsin B.

Detection Method: Fluorescence (Ex/Em = 400/505 nm)

Features & Benefits:

• Simple & convenient
• High-throughput adaptable assay to screen/study/characterize the potential inhibitors of Cathepsin B
• Cathepsin B inhibitor, F-F-FMK is included in the kit

Description:

Cathepsin B (CTSB, EC 3.4.22.1) is a lysosomal cysteine proteinase that is suggested to participate in intracellular degradation and turnover of proteins. It has also been implicated in tumor invasion and metastasis. Biovision’s Cathepsin B Inhibitor Screening Kit utilizes the ability of Cathepsin B to cleave the synthetic AFC based peptide substrate to release AFC, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin B-specific inhibitor, the cleavage of the substrate is reduced/abolished resulting in decrease or total loss of the AFC fluorescence. This simple and high-throughput adaptable assay kit can be used to screen/study/characterize the potential inhibitors of Cathepsin B.