Catharanthine sulfate

Catharanthine is a precursor of vinblastine-type alkaloids, found to have antitumor activity.Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.catharanthine can induce the self-association of tubulin into linear indefinite polymers with an efficacy that is 75% that of vinblastine or vincristine, the intrinsic dimerization constant for the liganded protein being K2 congruent to 1 x 10(5) M-1.