Caspase-8 Antibody

h1 class=titleCaspase-8 Antibody/h1
div id=node-1175 class=node ntype-antibodiesRabbit Polyclonal
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h4Catalog Number/h4
pstrong250576/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pCaspase-8 is the most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Caspase-8 binding to the adapter molecule FADD recruits the complex to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) triggers caspase-8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. The enzyme then cleaves and activates caspase-3, caspase-4, caspase-6, caspase-7, caspase-9 and caspase-10. Granzyme B and CPP32 cleave caspase-8 at Asp 315 and Asp 330 respectively to generate the two active subunits./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pCaspase-8; CASP-8; ICE-like apoptotic protease 5; MORT1-assiociated CED-3 homolog; MACH; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4;CASP8; MCH5/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.org/uniprot/Q14790Q14790/abr /
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Caspase-8./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pIP:Use at an assay dependent concentration/p
pstrongReacts with/strongnbsp; :H/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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