Caspase-8 (Active) Antibody
- 貨號 Cat. No.
- 3258-100
- 規格 Size
- 100 µg
Description
pstrongAntibody Target :/strongCaspase-8 (Active)/p
pbHost: /bMouse/p
pbAntibody Type: /bMonoclonal/p
pbIsotype: /bMouse IgG1/p
pbAntibody Form: /bAffinity Purified Antibody/p
pbImmunogen Sequence: /bSynthetic peptide derived from the amino-terminal sequence of p10 of human caspase-8/p
pbAccession#: /bBC006737/p
pbGene ID: /b12370/p
pbAppearance: /bColorless liquid/p
pbConcentration: /b0.2 ug/ml/p
pbFormulation: /b100 micro;g (200 micro;g/ml) affinity purified antibody in PBS containing 50% glycerol, 1% BSA, and 0.02% thimerosal./p
pbPurification: /bAffinity purified/p
pbSpecies Reactivity: /bhu/p
pbApplication: /bWB/IP/p
pbApplication amp; Usage: /bWestern blotting (0.5-4 micro;g/ml) and immunoprecipitation (10 micro;g/ml). However, the optimal conditions should be determined individually. Detects the 10 kDa small subunit of caspase-8. The antibody does not detect the full-length of caspase-8./p
pbStorage Temp.: /b-20 deg;C/p
pbShipping : /bgel pack/p
pbShelf Life: /b12 months/p
pbHandling: /bThe antibody solution should be gently mixed before use./p
pbBrief Background Descriptions: /bCaspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase-8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase-8 is able to cleave and activate downstream caspases, such as caspase-3, -6, -7 and a death agonist member of the Bcl-2/Bcl-xL family, Bid, leading to apoptosis./p
pbHost: /bMouse/p
pbAntibody Type: /bMonoclonal/p
pbIsotype: /bMouse IgG1/p
pbAntibody Form: /bAffinity Purified Antibody/p
pbImmunogen Sequence: /bSynthetic peptide derived from the amino-terminal sequence of p10 of human caspase-8/p
pbAccession#: /bBC006737/p
pbGene ID: /b12370/p
pbAppearance: /bColorless liquid/p
pbConcentration: /b0.2 ug/ml/p
pbFormulation: /b100 micro;g (200 micro;g/ml) affinity purified antibody in PBS containing 50% glycerol, 1% BSA, and 0.02% thimerosal./p
pbPurification: /bAffinity purified/p
pbSpecies Reactivity: /bhu/p
pbApplication: /bWB/IP/p
pbApplication amp; Usage: /bWestern blotting (0.5-4 micro;g/ml) and immunoprecipitation (10 micro;g/ml). However, the optimal conditions should be determined individually. Detects the 10 kDa small subunit of caspase-8. The antibody does not detect the full-length of caspase-8./p
pbStorage Temp.: /b-20 deg;C/p
pbShipping : /bgel pack/p
pbShelf Life: /b12 months/p
pbHandling: /bThe antibody solution should be gently mixed before use./p
pbBrief Background Descriptions: /bCaspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase-8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase-8 is able to cleave and activate downstream caspases, such as caspase-3, -6, -7 and a death agonist member of the Bcl-2/Bcl-xL family, Bid, leading to apoptosis./p