CAS (E2) Antibody

貨號 Cat. No.

BS1080

規格 Size

100μg

品牌 Brand

Bioworld

Description

stock

Host: Rabbit

Reactivity: Human

 

Product

1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Purification & Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity

CSE1L/Exportin-2 (E2) antibody detects endogenous levels of CSE1L/Exportin-2 protein.

Applications (Recommended Dilutions)

WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200 IF: 1:50~1:200

Western Blot(WB)

Western blot (WB) analysis of CSE1L/Exportin-2 (E2) antibody in extracts from 293 cells.

Immunohistochemistry (IHC)

Immunohistochemistry (IHC) analyzes of CSE1L/Exportin-2 (E2) antibody in paraffin-embedded human brain tissue.

Storage&Stability

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Background

Normal tissues are characterized by a balance between cellular stasis, cell proliferation, cell differentiation and cell death. Aberrant regulation of any of these cell processes can result in cancer. Cell death during embryogenesis, tissue atrophy and normal tissue turnover is called apoptosis. This is characterized by cytoplasmic and nuclear condensation, nuclear disorganization and fragmentation of genomic DNA into 180-200 base pair oligomers. Several human cDNA fragments have been shown to render MCF-7 cells resistant to cell death induced by Pseudomonas exotoxin, Pseudomonas exotoxin-derived immunotoxins, diptheria toxin and tumor necrosis factor (TNF). One such fragment has proven to be the human homolog to the yeast chromosome segregation homolog, CSE1. Cloning of the full-length human cDNA has revealed a putative protein designated CAS, for cellular apoptosis susceptibility, that is 971 amino acids in length with 59% overall sequence homology as compared to yeast CSE1. CAS is highly expressed in testis and fetal liver.

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