Capecitabine

Alternate Name/Synonyms: Pentyl[1-(3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl)- 5-fluoro-2-oxo-1H-pyrimidin- 4-yl]aminomethanoate; captabin; Ro 09-1978; Xabine

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 154361-50-9

Molecular Formula: C₁₅H₂₂FN₃O₆

Molecular Weight: 359.35

Purity: ≥99% by HPLC

Solubility: DMSO (100 mg/ml) or EtOH (10 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: A pre-prodrug of 5-fluorouracil (5-FU).  After oral uptake, capecitabine is first metabolized to 5'-deoxy-5-fluorocytidine (5'-DFCR), which occurs mainly in the liver by carboxyl-esterase.  The metabolite is converted to 5'-deoxy-5-fluoro-uridine (5'-DFUR) by cytidine deaminase in liver and tumor tissue.  Then 5'-DFUR is converted to 5-FU intracellularly by thymidine phosphorylase, which is often expressed in tumor tissue.

Handling: Protect from air and moisture