Canine TNF-alpha Protein, His Tag, active trimer (MALS verified)

Tumor necrosis factor alpha (TNF£) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNF£ is in the regulation of immune cells. TNF£ is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNF£ production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNF£ is used as an immunostimulant under the INN tasonermin. TNF£ can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.