CaMK2-a (K292) pAb
- 貨號 Cat. No.
- BS5510
- 規格 Size
- 100 μg
- 品牌 Brand
- Bioworld
Description
Product
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Purification & Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Specificity
CaMK2-a (K292) antibody detects endogenous levels of CaMK2-a protein.
Applications (Recommended Dilutions)
WB: 1:500~1:1000 IHC: 1:50~1:200
Western Blot(WB)
Western blot (WB) analyzes of CaMK2-a (K292) antibody in extracts from A431 cells.
Immunohistochemistry (IHC)
Immunohistochemistry (IHC) analyzes of CaMK2-a (K292) antibody in paraffin-embedded human A431 tissue.
Storage&Stability
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Background
The multifunctional CAMK2, or Ca2+/calmodulin-dependent protein kinase II, is a well known effector of calcium- and calmodulin- mediated functions. It is present in many tissues but is most abundant in the brain. CAMK2 is composed of four different chains: alph,a bet,a gamm,a and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Autophosphorylation plays an important role in the regulation of the kinase activity. CAMK2 is required for synaptic plasticity, as in Long Term Potentiation (LTP), a cellular model for learning and memory. CAMK2B is the beta chain. There are seven named isoforms produced by alternative splicing. The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms.CAMK2G is the gamma chain. CAMK2G has six alternatively spliced variants that encode six different isoforms. Some of these variants have been identified in human tumors.
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