C75

C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer. C75 inhibits FAS activity and stimulates carnitine palmitoyltransferase-1 (CPT-1) in primary cortical neurons, consistent with its effects in peripheral tissues. C75 alters neuronal ATP levels and AMP-activated protein kinase (AMPK) activity. C75 displays anorectic effects. C75 induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity. Several downstream pathways are affected by C75 treatment, including glucose metabolism and acetyl-CoA carboxylase (ACC) phosphorylation. C75 modulates the levels of energy intermediates, thus, affecting the energy sensor AMPK.