C5a Complement Antibody

C5 is part of the membrane attack complex (MAC) of the complement system. C5 is split into C5a and C5b by the C5 convertases from the classical and the alternative complement pathway and the C5b fragment initiates the assembly of the terminal MAC (C5b-C9). The molecular mass of C5 is 190 kDa. C5a is later cleaved into C5 anaphylatoxin, a mediator of local inflammation, and C5a'.