C4 Complement Antibody

The complement component C4 plays a central role in the activation of the classical pathway of the complement system. C4 is cleaved by activated C1 which removes the C4a anaphylatoxin from the alpha chain. The remaining active C4b fragment becomes a subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway. The C4a anaphylatoxin is a mediator of local inflammatory process. The C4A6 allotype is totally deficient in hemolytic activity. This antibody recognizes the human complement C4 in ELISA.