C-peptide (Rat) ELISA

pC-peptide (Rat) ELISA/p
div class=prod_specbFormat:/b/div
div class=prod_spec_infoELISA / EIA/div
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div class=prod_specSample Type:/div
div class=prod_spec_infoserum/div
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div class=prod_specbSample Size:/b/div
div class=prod_spec_info10 micro;l/div
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div class=prod_specbSize:/b/div
div class=prod_spec_info96 wells/div
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div class=prod_specbRange:/b/div
div class=prod_spec_info32 - 1800 pM/div
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div class=prod_specbSensitivity:/b/div
div class=prod_spec_info4.1 pM/div
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div class=prod_specbIncubation Time:/b/div
div class=prod_spec_info2 hour(s) 30 min(s)/div
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pbSummary:/b/p
Hyper-variation in the primary sequences of the two C-peptide proteins produced during proinsulin processing in rodents has hampered efforts to provide suitable immunologically-based assay systems for measuring C-peptide or proinsulin in rodent samples. When the efficiency of the proinsulin processing to insulin and c-peptide is disrupted, as in the diabetic or pre-diabetic state, proinsulin concentration is elevated relative to insulin or c-peptide concentration. The ratio of proinsulin to its metabolites may be an early marker of overall beta cell dysfunction, but the lack of rodent-specific assays has made this a difficult pathway to explore until now.
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