c-MET Protein, Cynomolgus, Recombinant (Fc Tag)

Hepatocyte growth factor receptor (HGFR), also known as c-Met or
mesenchymal-epithelial transition factor (MET), is a receptor tyrosine
kinase (RTK) that has been shown to be overexpressed and/or mutated in
a variety of malignancies. HGFR protein is produced as a single-chain
precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling
is essential for embryonic development, tissue repair or wound healing,
whereas aberrantly active HGFR has been strongly implicated in
tumorigenesis, particularly in the development of invasive and metastatic
phenotypes. HGFR protein is a multifaceted regulator of growth, motility,
and invasion, and is normally expressed by cells of epithelial origin.
Preclinical studies suggest that targeting aberrant HGFR signaling could be
an attractive therapy in cancer.