Bosutinib (SKI-606)

5 mg. Purity >98%. CAS# 380843-75-4. Inhibitors of SRC, ABL and TEC family kinases. It can cause a decrease in cell motility and invasion of breast cancer cell lines with an IC50 of ?250 nmol/L, which was also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells. SKI-606 inhibits the phosphorylation of focal adhesion kinase (FAK), proline-rich tyrosine kinase 2 (Pyk2), and Crk-associated substrate (p130Cas), with an IC50 similar to inhibition of cellular Src kinase. A promising therapeutic for breast cancer. Soluble in DMSO. Store cool and dry at -20C. Protect from light.