Bok Antibody
- 貨號 Cat. No.
- 3043-100
- 規格 Size
- 100 µg
Description
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pstrongAntibody Target :/strongBok/p
pstrongemHost: Rabbit /em/strong/p
pstrongemAntibody Type: Polyclonal /em/strong/p
pstrongemIsotype: Rabbit IgG /em/strong/p
pstrongemAntibody Form: Affinity Purified Antibody /em/strong/p
pstrongemImmunogen Sequence: Synthetic peptide surrounding amino acid 44 of rat BOK /em/strong/p
pstrongemAccession#: EAW71269 /em/strong/p
pstrongemGene ID: 666 /em/strong/p
pstrongemAppearance: Colorless liquid /em/strong/p
pstrongemConcentration: 0.2 mg/ml /em/strong/p
pstrongemFormulation: 100 micro;g (0.2 mg/ml) peptide affinity purified rabbit anti-Bok polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal. /em/strong/p
pstrongemPurification: Affinity purified /em/strong/p
pstrongemSpecies Reactivity: ms/rt /em/strong/p
pstrongemApplication: WB /em/strong/p
pstrongemApplication amp; Usage: Western blot analysis (0.5-4 micro;g/ml). /em/strong/p
pstrongemStorage Temp.: -20 deg;C /em/strong/p
pstrongemShipping : gel pack /em/strong/p
pstrongemShelf Life: 12 months /em/strong/p
pstrongemHandling: The antibody solution should be gently mixed before use. /em/strong/p
pstrongemBrief Background Descriptions: Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus./em/strong/p
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pnbsp;/p
pstrongAntibody Target :/strongBok/p
pstrongemHost: Rabbit /em/strong/p
pstrongemAntibody Type: Polyclonal /em/strong/p
pstrongemIsotype: Rabbit IgG /em/strong/p
pstrongemAntibody Form: Affinity Purified Antibody /em/strong/p
pstrongemImmunogen Sequence: Synthetic peptide surrounding amino acid 44 of rat BOK /em/strong/p
pstrongemAccession#: EAW71269 /em/strong/p
pstrongemGene ID: 666 /em/strong/p
pstrongemAppearance: Colorless liquid /em/strong/p
pstrongemConcentration: 0.2 mg/ml /em/strong/p
pstrongemFormulation: 100 micro;g (0.2 mg/ml) peptide affinity purified rabbit anti-Bok polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal. /em/strong/p
pstrongemPurification: Affinity purified /em/strong/p
pstrongemSpecies Reactivity: ms/rt /em/strong/p
pstrongemApplication: WB /em/strong/p
pstrongemApplication amp; Usage: Western blot analysis (0.5-4 micro;g/ml). /em/strong/p
pstrongemStorage Temp.: -20 deg;C /em/strong/p
pstrongemShipping : gel pack /em/strong/p
pstrongemShelf Life: 12 months /em/strong/p
pstrongemHandling: The antibody solution should be gently mixed before use. /em/strong/p
pstrongemBrief Background Descriptions: Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus./em/strong/p
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pnbsp;/p