Bnip3L Polyclonal Antibody
- 貨號 Cat. No.
- 3205-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/antibody-stock-miva.jpg alt= //p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 80 of human Bnip3L/p
pbFORMULATION:/b 100 ug (0.5 mg/ml) affinity purified rabbit anti-Bnip3L polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 1% BSA, 0.02% thimerosal./p
pbSPECIES REACTIVITY:/b human, mouse/p
pbSTORAGE CONDITIONS:/b Store at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND:/b Members of Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3?, and Nix (for Nip3-like protein X). Bnip3L/Bnip3?/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes supression by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The message RNA of Bnip3L and Bnip3 form a new subfamily of the proapoptotic mitochondrial proteins./p
pbAPPLICATION AND USAGE:/b The antibody can be used for Western blot analysis (0.5-2 ug/ml) and immunohistochemistry (2-10 ug/ml). The optimal conditions should be determined individually. Other applications have not been tested./p
pbSPECIFICITY:/b The immunoaffinity purified antibody detects a ~40 kDa human and mouse Bnip3L. K562 cell lysate can be used as a positive control. FOR RESEARCH PURPOSE ONLY! Not to be used in human./p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 80 of human Bnip3L/p
pbFORMULATION:/b 100 ug (0.5 mg/ml) affinity purified rabbit anti-Bnip3L polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 1% BSA, 0.02% thimerosal./p
pbSPECIES REACTIVITY:/b human, mouse/p
pbSTORAGE CONDITIONS:/b Store at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND:/b Members of Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3?, and Nix (for Nip3-like protein X). Bnip3L/Bnip3?/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes supression by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The message RNA of Bnip3L and Bnip3 form a new subfamily of the proapoptotic mitochondrial proteins./p
pbAPPLICATION AND USAGE:/b The antibody can be used for Western blot analysis (0.5-2 ug/ml) and immunohistochemistry (2-10 ug/ml). The optimal conditions should be determined individually. Other applications have not been tested./p
pbSPECIFICITY:/b The immunoaffinity purified antibody detects a ~40 kDa human and mouse Bnip3L. K562 cell lysate can be used as a positive control. FOR RESEARCH PURPOSE ONLY! Not to be used in human./p