BK Channel Antibody

Catalog Number

250561

Unit

0.1 mg

 

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography

Data and Images

Description

The BK channel (calcium-activated potassium channel subunit alpha-1 or KCNMA1) is a potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). BK channel is also activated by the concentration of cytosolic Mg(2+). BK channel has a key role in controlling excitability in a numerous systems, such as smooth muscle contraction, tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD).

Product Citations

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Alternate Names

Calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel, subfamily M subunit alpha-1; Maxi K channel; MaxiK; BK channel; K(VCA)alpha; BKCA alpha; KCa1.1; Slowpoke homolog; slo homolog; Slo-alpha; Slo1; hSlo; KCNMA1; KCNMA; SLO

Accession No.

Q12791

 

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BK channel.

Application Notes

E: 1:500-1:1,000

WB: 1:200-1:500

IHC: 1:200-1:500

Reacts with  :Mk | H | M | R | Other

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.