BIX 02189
Chemical Compounds
- 貨號 Cat. No.
- M2316
- 規格 Size
- 10mg,50mg,100mg
- 品牌 Brand
- No Brand
Description
BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. BIX 02189 inhibited catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells. BIX 02189 also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system.
