Biotinylated Mouse BAFFR / TNFRSF13C Protein, Fc,Avitag™

Source : 

Biotinylated Mouse BAFFR, Fc,Avitag (BAR-M82F0) is expressed from human 293 cells (HEK293). It contains AA Ser 10 - Ala 71 (Accession # NP_082351).

 

Molecule : BAFFR

 

Synonyms : BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_082351

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 35.1 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 35.1 kDa. As a result of glycosylation, the protein migrates as 45-60 kDa under reducing (R) condition, and 90-116 kDa under no

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

 

References :

(1)Thompson JS., et al.,2001, Science, 293 (5537): 2108-2111.
(2)Mbrose CM., 2003, Journal of Biological Regulators and Homeostatic Agents, 16 (3): 211-213.
(3)Treml LS., et al., 2006, Seminars in Immunology, 18 (5): 297-304.