Biotinylated Human TPBG / 5T4 Protein, His,Avitag™

Source : 

Biotinylated Human TPBG, His,Avitag (TPG-H82Eb) is expressed from human 293 cells (HEK293). It contains AA Ser 32 - Ser 355 (Accession # Q13641-1).

 

Molecule : TPBG

 

Synonyms : TPBG,5T4,M6P1,5T4AG,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_006661.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 39.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 39.0 kDa. The protein migrates as 50-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.

 

References :

(1) Hu G, et al., 2015, Mol Pharm., 12(6), 1730-7.
(2) Stern PL, et al., 2017, Cancer Immunol Immunother., 66(4), 415-426.
(3) Stern PL, et al., 2014, Semin Cancer Biol., 29, 13-20.