Biotinylated Human TACI / TNFRSF13B Protein, Fc,Avitag™

Source : 

Biotinylated Human TACI, Fc,Avitag (TAI-H82F6) is expressed from human 293 cells (HEK293). It contains AA Ser 2 - Thr 166 (Accession # O14836-1).

 

Molecule : TACI

 

Synonyms : CD267,TACI,TNFRSF13B

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_036584.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 46.7 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 46.7 kDa. The protein migrates as 33-40 kDa and 47-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B). It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL.
The present study demonstrated that, in NSCLC, a proliferation-inducing ligand (APRIL), B-cell maturation antigen (BCMA)and transmembrane activator and CAML interactor (TACI) proteins are abnormally expressed by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blotting. In addition, the expression of APRIL, BCMA and TACI were observed to be involved in extracellular signal-regulated kinase (ERK)1/2 activation in A549 cells.

 

References :

(1) Dou, H., et al., 2016, Oncology Letters., 12(5), 3351–3355. (2) Van Attekum, M., 2016, Cell Death Discovery, 2, 16020 (3) Cole, M. B., 2016, Arthritis & Rheumatology (Hoboken, N.j.), 68(12), 2936–2944