Biotinylated Human SLAMF1 / SLAM / CD150 Protein, His,Avitag™

Source : 

Biotinylated Human SLAMF1, His,Avitag (SL1-H82E3) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Pro 237 (Accession # Q13291-1).

 

Molecule : SLAMF1

 

Synonyms : SLAMF1,CD150,CDw150,SLAM,IPO-3

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_003028.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 28.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 28.0 kDa. The protein migrates as 42-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, also known as CD150, is the prototypic member of the SLAM subfamily of the CD2 protein family.SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. The type I transmembrane glycoprotein Signaling Lymphocytic Activation Molecule (SLAM).

 

References :

(1) Cannons JLt, et al., 2011, Annu Rev Immunol., 29, 665-705.
(2) Jordan MA, et al., 2011, J Immunol., 186(7), 3953-65.
(3) Berger SB, et al., 2010, Nat Immunol., 11(10), 920-7.