Biotinylated Human Serum Albumin Protein, His,Avitag™

Source : 

Biotinylated Human Serum Albumin, His,Avitag (HSA-H82E3) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Leu 609 (Accession # P02768-1).

 

Molecule : Serum Albumin

 

Synonyms : Serum albumin,ALB,Alb

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_000468.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 70.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 70.2 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

serum albumin (SA) is also known as ALB, which is the main protein of plasma and has a good binding capacity for water,Ca2+,Na+,K+,fatty acids,hormones, bilirubin and drugs.The main function of SA is the regulation of the colloidal osmotic pressure of blood. As Major zinc transporter in plasma, SA typically binds about 80% of all plasma zinc. A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. Defects in serum albumin can cause familial dysalbuminemic hyperthyroxinemia which is a form of euthyroid hyperthyroxinemia that is due to increased affinity of serum albumin for T4. It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.

 

References :

(1) Carter D.C., et al., 1989, Science 244:1195-1198.
(2) Minchiotti L., et al., Eur. 2001, J. Biochem. 268:344-352.
(3) Minchiotti L., et al., 1992, Biochim. Biophys. Acta 1119:232-238.