Biotinylated Human NKp46 / NCR1 / CD335 Protein, Fc,Avitag™

Source : 

Biotinylated Human NKp46, Fc,Avitag (NC1-H82F9) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Asn 254 (Accession # AAH64806).

 

Molecule : NKp46

 

Synonyms : NCR1,LY94,CD335,NK-p46,hNKp46

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_001138929.2(K82Q)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 54.7 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 54.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

 

References :

(1) Pessino A., et al., 1998, J. Exp. Med. 188:953-960.