Biotinylated Human Nectin-2 / CD112 Protein, Fc,Avitag™

Source : 

Biotinylated Human Nectin-2, Fc,Avitag (CD2-H82F8) is expressed from human 293 cells (HEK293). It contains AA Gln 32 - Leu 360 (Accession # Q92692-2).

 

Molecule : Nectin-2

 

Synonyms : CD112,Nectin-2,PVRL2

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_002847.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 64.0 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 64.0 kDa. As a result of glycosylation, the protein migrates as 66 kDa under reducing (R) condition, and 130 kDa under non-redu

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

 

References :

(1) Martinez W.M., et al., 2001, J. Virol. 75:11185-11195.
(2) Yu X., et al., 2009, Nat. Immunol. 10:48-57.