Biotinylated Human LILRA6 / CD85b / ILT8 Protein, His,Avitag™

Source : 

Biotinylated Human LILRA6, His,Avitag (LI6-H82E2) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Asn 447 (Accession # Q6PI73-1).

 

Molecule : LILRA6

 

Synonyms : LILRA6,CD85b,ILT8,ILT-8

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : AGZ61988.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 50.0 kDa. The protein migrates as 56-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

The LILRs are a family of receptors that regulate the activities of myelomonocytic cells. LILRB3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 (ILT5) and LILRA6 (ILT8) are highly polymorphic receptors with similar extracellular domains. LILRA6 can signal through association with an activating adaptor molecule, FcRγ, which bears a cytoplasmic tail with an immunoreceptor tyrosine-based activation motif. Analysis of mRNA expression in the major fractions of PBMCs showed that LILRA6 is primarily expressed in monocytes, and its expression level correlates with copy number of the gene.

 

References :

(1) Jones DC., et al., 2016, Oncotarget. 7:15618-15631.
(2) Bashirova AA., et al., 2014, Immunogenetics. 66:1-8.
(3) López-Álvarez MR., et al., 2016, Immunogenetics. 68:743-747.