Biotinylated Human LILRA3 / CD85e Protein, His,Avitag™

Source : 

Biotinylated Human LILRA3, His,Avitag (LI3-H82E0) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Glu 439 (Accession # AAH28208.1).

 

Molecule : LILRA3

 

Synonyms : LILRA3,ILT6,LIR4,CD85e

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : AAH28208.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 48.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 48.7 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3) is also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the eukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain, which contains 4 Ig-like C2-type (immunoglobulin-like) domains. LILRA3 acts as soluble receptor for class I MHC antigens. At the same time,LILRA3 can bind both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Also,LILRA3 can bind with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

 

References :

(1) Arm J.P., et al., 1997, J. Immunol. 159:2342-2349.
(2) Borges L., et al., 1997, J. Immunol. 159:5192-5196.
(3) Ryu M., et al., 2011, PLoS ONE 6:E19245-E19245.