Biotinylated Human LILRA2 / CD85h / ILT1 Protein, His,Avitag™

Source : 

Biotinylated Human LILRA2, His,Avitag (LI2-H82E9) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Asn 449 (Accession # Q8N149-1).

 

Molecule : LILRA2

 

Synonyms : ILT1,LIR7,CD85H,LIR-7,LILRA2,ILT1CD85H,CD85h,ILT1,ILT-1,ILT1CD85H,CD85h antigen,CD85 antigen-like family member H

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : Q8N149.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 50.7 kDa. The protein migrates as 67-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

LILRA2 (Leukocyte immunoglobulin like receptor A2), also known as CD85H and LIR7 (Leukocyte immunoglobulin-like receptor 7). It belongs to the subfamily A class of LIR receptors (LILRAs), which are single-pass type I transmembrane proteins with 2-4 extracellular Ig-like domains, a transmembrane domain (TM), and a short cytoplasmic tail. LILRA2 contains 4 Ig-like C2 type domains in the extracellular region. LILRA2 does not bind class I MHC antigens. LILRA2 is expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. LILRA2 is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response.

 

References :

(1) Hirayasu K., et al., 2016, Nat Microbiol.,1(6), 16054.
(2) Brown D., et al., 2004, Tissue Antigens.,64(3), 215-25.
(3) MacGlashan DW Jr1., et al.,2008, J Immunol., 180(6), 4208-17.