Biotinylated Human IL-7 R alpha / CD127 Protein, Fc,Avitag™

Source : 

Biotinylated Human IL-7 R alpha, Fc,Avitag (IL7-H82F8) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Gly 236 (Accession # P16871-1).

 

Molecule : IL-7 R alpha

 

Synonyms : IL7Ra,CD127

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : N/A

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 53.3 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 53.3 kDa. As a result of glycosylation, the protein migrates as 70-100 kDa under reducing (R) condition, and 130-200 kDa under

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Interleukin-7 receptor subunit alpha (IL-7 RA or IL7Ra) is also known as cluster of differentiation 127 (CD127). IL-7 RA is a type I cytokine receptor and is a subunit of the functional Interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors. IL-7 RA has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination[citation needed]. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation.

 

References :

(1) Sanyal M., et al., 2015, Clin Immunol., 161 (2): 355-365.
(2) Goodwin RG., et al., 1990, Cell, 60 (6): 941-951.
(3) Zenatti PP., et al., 2011, Nature Genetics, 43 (10): 932-939.