Biotinylated Human IL-17A / CTLA-8 Protein, His,Avitag™

Source : 

Biotinylated Human IL17A, His,Avitag (ILA-H82Q1) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Ala 155 (Accession # Q16552-1).

 

Molecule : IL-17A

 

Synonyms : IL-17A,Interleukin-17A,CTLA-8,IL-17

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_002181.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 17.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 17.8 kDa. The protein migrates as 19-21 kDa and 23-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

 

References :

(1) Yao Z., et al.,1995, J. Immunol. 155:5483-5486.
(2) Gerhardt S., et al., 2009, J. Mol. Biol. 394:905-921.