Biotinylated Human IL-17 RA / CD217 Protein, His,Avitag™

Source : 

Biotinylated Human IL-17 RA, His,Avitag (ILR-H82E5) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (Accession # Q96F46-1).

 

Molecule : IL-17 RA

 

Synonyms : CD217,CDw217,IL-17RA,IL17R,CANDF5,hIL-17R

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_055154.3

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 37.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 37.2 kDa. The protein migrates as 55-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interleukin-7 receptor subunit alpha (IL-7 RA or IL7Ra) is also known as cluster of differentiation 127 (CD127). IL-7 RA is a type I cytokine receptor and is a subunit of the functional Interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors. IL-7 RA has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination[citation needed]. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation.

 

References :

(1) Sanyal M., et al., 2015, Clin Immunol., 161 (2): 355-365.
(2) Goodwin RG., et al., 1990, Cell, 60 (6): 941-951.
(3) Zenatti PP., et al., 2011, Nature Genetics, 43 (10): 932-939.