Biotinylated Human Growth Hormone R (GHR) Protein, His Tag, ultra sensitivity (primary amine labeling)

Source : 

MABSol® Biotinylated Human GHR, His Tag, ultra sensitivity (primary amine labeling) (GHR-H8222) is expressed from human HEK293 cells. It contains AA Ala 27 - Tyr 264 (Accession # P10912-1). It is the biotinylated form of Human Growth Hormone R (GHR) Protein (GHR-H5222).

 

Molecule : Growth Hormone R

 

Synonyms : GHR,GHBP,GH receptor

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_000154.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 29.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.6 kDa. The protein migrates as 40-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

 

References :

(1) Duquesnoy P., et al., 1994, EMBO J. 13:1386-1395.
(2) Urbanek M., et al., 1993, J. Biol. Chem. 268:19025-19032.