Biotinylated Human GITR / TNFRSF18 Protein, His,Avitag™

Source : 

Biotinylated Human GITR, His,Avitag (GIR-H82E4) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Glu 161 (Accession # Q9Y5U5-1).

 

Molecule : GITR

 

Synonyms : AITR,GITR,TNFRSF18,CD357

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_004186.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 18.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 18.1 kDa. The protein migrates as 22-26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

 

References :

(1) Gurney A.L., et al., 1999, Curr. Biol. 9:215-218.
(2) Park MS., et al., 2007, Yonsei Med J 48 (5): 839-46.