Biotinylated Human G-CSF R / CD114 Protein, Avitag™,His Tag

Source : 

Biotinylated Human G-CSF R, Avitag,His Tag (GCR-H82E4) is expressed from human 293 cells (HEK293). It contains AA Glu 25 - Pro 621 (Accession # NP_000751).

 

Molecule : G-CSF R

 

Synonyms : CSF3R,CD114,GCSFR

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_000751

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 69.2 kDa

 

Characteristics :

This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 69.2 kDa. The protein migrates as 72-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. Granulocyte colony-stimulating factor receptor has been shown to interact with Grb2, HCK and SHC1. The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.

 

References :

(1)Zeidler C., Welte K., 2002, Semin. Hematol., 39 (2): 82-88.
(2)Beekman R., Touw IP., 2010, Blood, 115 (25): 5131-5136.
(3)Ehlers S., 2010, J. Clin. Oncol., 28 (15): 2591-2597.