Biotinylated Human FGL1 Protein, Avitag™,Fc Tag

Source : 

Biotinylated Human FGL1, Avitag,Fc Tag (FG1-H82F4) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Ile 312 (Accession # Q08830-1).

 

Molecule : FGL1

 

Synonyms : FGL1,Hepassocin,HP-041,HFREP-1,LFIRE-1,HFREP1

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_004458.3

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 62.1 kDa

 

Characteristics :

This protein carries an Avi tag (Avitag™) at the N-terminus, followed by a human IgG1 Fc tag. The protein has a calculated MW of 62.1 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1. The protective effect of fibrinogen-like protein 1 (FGL1) in liver injury has previously been reported. However, studies have shown that FGL1 may be a predictor of GC patients and a target for GC therapy. Immunocytochemical studies revealed that fgl1 selectively binds to defective spermatozoa in the cauda epididymidis. Northern blot analysis and in situ hybridization demonstrated the high expression of fgl1 in the principal cells of the proximal cauda epididymidis. Immunofluorescence analysis using mouse fibrotic lung tissues suggested that fibrotic regions showed increased expressions of Gtse1 and Fgl1, Gtse1 and Fgl1 are suggested to be novel targets for radiation-induced lung fibrosis.

 

References :

(1) Nagdas SK. 2016. Int J Biochem Cell Biol. 80:163-172.
(2) Jin H. 2018 Nov 7. J Mol Med (Berl).
(3) Zhang Y. 2018 Aug. Mol Med Rep. 18(2):1465-1472.