Biotinylated Human CEACAM-5 / CD66e Protein, His,Avitag™

Source : 

Biotinylated Human CEACAM-5, His,Avitag (CE5-H82E0) is expressed from human 293 cells (HEK293). It contains AA Lys 35 - Ala 685 (Accession # P06731-1).

 

Molecule : CEACAM-5

 

Synonyms : CEACAM-5,CD66e,CEA,Meconium antigen 100

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_004354.3

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 75.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 75.0 kDa. The protein migrates as 90-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 20 mM Tris, 150 mM Potassium glutamate, pH7.5

 

Description :

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is also Carcinoembryonic antigen (CEA), Meconium antigen 100, CD antigen CD66e, CEACAM5 belongs to the immunoglobulin superfamily and CEA family. CEACAM5 contains seven Ig-like (immunoglobulin-like) domains. CEACAM5 is homodimer protein which binding of E.coli Dr adhesins leads to dissociation of the homodimer. CEACAM5 is cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. CEACAM5 is receptor for E.coli Dr adhesins.

 

References :

(1) Taheri M., et al., 2000, J. Biol. Chem. 275:26935-26943.
(2) Korotkova N., et al., 2008, Mol. Microbiol. 67:420-434.