Biotinylated Human BLAME / SLAMF8 Protein, His,Avitag™

Source : 

Biotinylated Human BLAME, His,Avitag (BLE-H82E4) is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Asp 233 (Accession # Q9P0V8-1).

 

Molecule : BLAME

 

Synonyms : BLAME,SLAMF8,CD353

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_064510.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 27.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 27.1 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Sodium Citrate, 150 mM NaCl, pH5.5

 

Description :

BLAME (B-lymphocyte activator macrophage expressed) is also known as SLAM family member 8(SLAMF8), CD353. BLAME is a cell surface receptor that is expressed upon activation of macrophages (MΦs) by IFN-γ or bacteria, is a negative regulator of ROS in response to Gram+ and Gram- bacteria. May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. SLAMF8 is a costimulatory molecule that affects the activation of macrophages in inflammation and in immunosuppression and inflammation response to glioma cells could aid immunotherapy for glioma.

 

References :

(1) Zou CY, et al. 2018. CNS Neurosci Ther. doi: 10.1111/cns.13041.
(2) Wang G, et al. 2012. J Immunol. 188(12):5829-32.
(3) Wang G, et al. 2015. PLoS One. 10(3):e0121968.