Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Fc,Avitag™

Source : 

Biotinylated Human B7-H5, Fc,Avitag (B75-H82F3) is expressed from human 293 cells (HEK293). It contains AA Phe 33 - Ala 194 (Accession # AAH20568.1).

 

Molecule : B7-H5

 

Synonyms : B7-H5,SISP1,Gi24,VISTA

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : AAH20568.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 47.1 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 47.1 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

 

References :

(1) Sakr M.A., et al., 2010, Cancer Sci., 101: 2368-2374.
(2) Mayya V., et al ., 2009, Sci. Signal., 2: RA46-RA46.