Biotinylated Human B7-H3 (4Ig) / B7-H3b Protein, His,Avitag™

Source : 

Biotinylated Human B7-H3 (4Ig), His,Avitag (B7B-H82E8) is expressed from human 293 cells (HEK293). It contains AA Gly 27 - Thr 461 (Accession # Q5ZPR3-1).

 

Molecule : B7-H3 (4Ig)

 

Synonyms : 4Ig-B7-H3,B7-H3,CD276,PSEC0249,UNQ309/PRO352,B7 homolog 3

 

Format : Powder

 

Category : MABSol® Biotin Labeled Proteins

 

Accession : NP_001019907.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 50.3 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Human B7 homolog 3 (B7-H3) is a member of the B7 family of immune proteins that provide signals for the regulation of immune responses. Other family members include B7-1, B7-2, B7-H1/PD-L1, B7-H2, and PD-L2. B7 family proteins are type I transmembrane immunoglobulin (Ig) superfamily members that contain extracellular Ig V‑like and Ig C‑like domains with a short cytoplasmic tail. Termed 4IgB7-H3 or B7-H3b, this molecule has two additional Ig-like domains (one V‑type and one C‑type) and shows a ubiquituous expression pattern.

 

References :

(1) Chapoval AI., et al. 2001, Nat Immunol., 2(3), 269-74.
(2) Steinberger P., et al. 2004, J Immunol., 172(4), 2352-9.
(3) Sun M., et al. 2002, J Immunol., 168(12), 6294-7.