Biotinylated Cynomolgus Fc gamma RIIB / CD32b Protein, His,Avitag? (SPR & BLI & MALS verified)
- 貨號 Cat. No.
- CDB-C82E4
- 規格 Size
- 200ug
- 品牌 Brand
- ACROBiosystems
- Species
- Cynomolgus
- Conjugate
- Precision Avi
- Expression System
- HEK293
- Tag
- His Tag & Avi Tag
Description
Receptors for the Fc region of IgG (Fc £^ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc £^ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized.
There are three genes for human Fc£^ RII /CD32 (A, B, and C) and one for mouse Fc£^ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
There are three genes for human Fc£^ RII /CD32 (A, B, and C) and one for mouse Fc£^ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
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