BIBW2992
Chemical Compounds
- 貨號 Cat. No.
- M1677
- 規格 Size
- 10mg,50mg,100mg
- 品牌 Brand
- No Brand
Description
BIBW2992 (Afatinib) is a novel irreversible dual EGFR and HER2 tyrosine kinase inhibitor. The potency of BIBW2992 on the EGFR and HER2 kinases revealed IC50 values of 0.5 nM and 14 nM, respectively. BIBW2992 suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines and induces tumor regression in xenograft and transgenic lung cancer models, with superior activity over erlotinib.
