Beta-Amyloid [1-28] Antibody

Catalog Number

250922

Unit

0.1 mg

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

Beta-amyloid production results from cleavage in the extracellular domain of APP by the beta-secretase (BACE1) , which results in the production of the APP  C-terminal fragment C99. This fragment is further cleaved by the gamma-secretase at residues 40-42 to produce beta-amyloid 40 and 42 peptides. Beta-amyloid aggregation and neuritic plaque formation are pathologic hallmarks of Alzheimer disease. This fragment is the amino terminus (1-28) of beta amyloid.

Product Citations

Recommended Products

Alternate Names

APP;  ABPP;  Alzheimer disease amyloid protein;  Cerebral vascular amyloid peptide; CVAP;  Protease nexin-II;  PN-II;  APPI;  PreA5

Accession No.

P05067

 

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing the sequence (1-28) of human Beta Amyloid.

Application Notes

E: 1:500-1:1,000;

WB: 1:100-1:500;

IHC: 1:200-1:500

IP:Use at an assay dependent concentration

Reacts with  :H | M | R

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.