BCRP Antibody

Breast cancer resistance protein (BCRP) is a xenobiotic transporter with an important role in the exclusion of xenobiotics from the brain. BCRP is also involved in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase int he efflux of rhodamine 123.