Bcl-2 Antibody

Catalog Number

250555

Unit

0.1 mg

 

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability. Bcl-2 functions in a feedback loop system with caspases by inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria or by binding to the apoptosis-activating factor (APAF-1).

Product Citations

Recommended Products

Alternate Names

Apoptosis regulator Bcl-2; BCL2

Accession No.

P10415

 

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Bcl-2.

Application Notes

E: 1:500-1:1,000

WB: 1:200-1:500

IHC: 1:200-1:500

IP:Use at an assay dependent concentration

Reacts with  :H | M | R

Storage

<p> Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. </p>