Catalog Number250843 Unit0.1 mg FormatEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Data and Images | DescriptionThe Bel-2 gene was isolated at the chromosonal breakpoint of t(14:18)-bearing follicular B cell lymphomas (1,2) Bel-2 bloacks cell death following a variety of stimuli and confers a death sparing effect to a certain hematopoieticcell lines following growth factor withdrawal ( 3, 5). Bel 2 appears to function in several subcellulart locations yet lacks any known motifs that would confer insight into its mechanism of action (6, 7). A morerecently identified protein, designated as Bax p21 ( i,e, Bel associated X protein) has exstensive amino acid homology with Bel-2 and both homodimerizes and forms heterodimers with Bel-2(8). Overexpression of Bax accelrates apoptotic death induced by cytokinedeprivation in an Il-3 dependent cell line and Bax also counters the death repressor activity of Bel-2 (8). Product Citations
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Alternate Names
Accession No.
Clonality
Antigen
KLH-conjugated synthetic peptide encompassing a sequence within the N/C-term region of human protein.
Application Notes
E: 1:500-1:1,000 WB: 1:200-1:500 IHC: 1:200-1:500 Reacts with :H | M | R
StorageStore at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |