Bax Antibody

Catalog Number

250758

Unit

0.1 mg

 

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

Apoptosis regulator BAX (BAX or Bcl-2-like protein 4) accelerates programmed cell death by binding to and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. BAX induces the release of cytochrome c, activation of caspase-3 and apoptosis. BAX forms heterodimers with BCL2, Bcl-X(L), MCL1 and A1 by interacting with BH3 domains in BIK, BID, BAK, and BAD. Defects in BAX are found in some cell lines from hematopoietic malignancies.

Product Citations

Recommended Products

Alternate Names

Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4; BAX; BCL2L4

Accession No.

Q07812

 

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human BAX.

Application Notes

E: 1:500-1:1,000

WB: 1:100-1:500

IHC: 1:200-1:500

Reacts with  :H | M | R| Other

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.