BAFF-R Polyclonal Ab
- 貨號 Cat. No.
- 3578-100
- 規格 Size
- 100 ug
Description
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pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide mapping to the C-terminus of human BAFF-R/p
pbFORMULATION: /b100 ug (0.5 mg/ml) affinity purified rabbit anti-BAFF-R polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal./p
pbSPECIES REACTIVITY: /bhuman, mouse, rat/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles. BACKGROUND: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-?B and c-Jun N-terminal kinase./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blotting (2-6 ug/ml) and immunohistochemistry (10-20 ug/ml). However, the optimal conditions should be determined individually. Human spleen tissue lysate can be used as a positive control./p
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pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide mapping to the C-terminus of human BAFF-R/p
pbFORMULATION: /b100 ug (0.5 mg/ml) affinity purified rabbit anti-BAFF-R polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal./p
pbSPECIES REACTIVITY: /bhuman, mouse, rat/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles. BACKGROUND: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-?B and c-Jun N-terminal kinase./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blotting (2-6 ug/ml) and immunohistochemistry (10-20 ug/ml). However, the optimal conditions should be determined individually. Human spleen tissue lysate can be used as a positive control./p